Leonard Shelby is determined to take revenge on someone who killed his wife. However, he suffered from short-term amnesia which required him to take notes, take pictures, and tattoo his body.
Leonard Shelby bertekad membalas dendam kepada seseorang yang telah membunuh istrinya. Namun, ia mengidap amnesia jangka pendek yang mengharuskannya mencatat, memotret, hingga mentato tubuhnya.